Arachidonoyl-Specific Diacylglycerol Kinase ε and the Endoplasmic Reticulum
نویسندگان
چکیده
منابع مشابه
Arachidonoyl-Specific Diacylglycerol Kinase ε and the Endoplasmic Reticulum
The endoplasmic reticulum (ER) comprises an interconnected membrane network, which is made up of lipid bilayer and associated proteins. This organelle plays a central role in the protein synthesis and sorting. In addition, it represents the synthetic machinery of phospholipids, the major constituents of the biological membrane. In this process, phosphatidic acid (PA) serves as a precursor of al...
متن کاملDiacylglycerol Kinase-ε: Properties and Biological Roles
In mammals there are at least 10 isoforms of diacylglycerol kinases (DGK). All catalyze the phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PA). Among DGK isoforms, DGKε has several unique features. It is the only DGK isoform with specificity for a particular species of DAG, i.e., 1-stearoyl-2-arachidonoyl glycerol. The smallest of all known DGK isoforms, DGKε, is also the only DG...
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Phosphatidylinositol (PI) is essential for numerous cell functions and is generated by consecutive reactions catalyzed by CDP-diacylglycerol synthase (CDS) and PI synthase. In this study, we investigated the membrane organization of CDP-diacylglycerol synthesis. Separation of mildly disrupted A431 cell membranes on sucrose density gradients revealed cofractionation of CDS and PI synthase activi...
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The recent discovery of mutations in the gene encoding diacylglycerol kinase ε (DGKE) identified a novel pathophysiologic mechanism leading to HUS and/or MPGN. We report ten new patients from eight unrelated kindreds with DGKE nephropathy. We combined these cases with all previously published cases to characterize the phenotypic spectrum and outcomes of this new disease entity. Most patients pr...
متن کاملThe Endoplasmic Reticulum
Original Findings on Cultured MateriaL--The relatively short history of the endoplasmic reticulum started 10 years ago, in 1945, when Porter, Claude, and Fullam (1), noted the presence of a "lace-like" reticulum in the ground substance of ceils grown in tissue culture and examined in toto in the electron microscope. In describing their findings, these authors mentioned that "at higher magnifica...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2016
ISSN: 2296-634X
DOI: 10.3389/fcell.2016.00132